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You Need to Know everything about the COVID-19 Vaccine

sciencefocus: Up to 30 million doses of a COVID-19 vaccine could be available to the UK by September if the vaccine candidate developed by Oxford University proves successful in human trials, the government has said.

Business Secretary Alok Sharma said the first clinical trials were “progressing well” and that all phase one volunteers had received their vaccine dose “on schedule earlier this week”.

Researchers at the Oxford Vaccine Group began testing the vaccine candidate, called ChAdOx1 nCoV-19, in humans last month, 24 April, to see whether it can protect healthy people from COVID-19.

The programme will allow researchers to assess the safety of the candidate, and its ability to generate an immune response.

The vaccine will be given to half the participants, while the remaining volunteers are given a licensed meningitis vaccine to be used as a control.

When analysing results, statisticians will compare the number of infections in the control group with the number of infections in the vaccinated group. Therefore, it is necessary for a small number of study participants to develop COVID-19.

In the coronavirus daily briefing on 17 May, the government announced its pledge to invest an extra £84m into the University of Oxford’s search for a vaccine. Sharma also said £38m will be put towards building a “rapid deployment facility” to ensure any successful vaccine is made widely-available.

There are various vaccine candidates being trialled currently. In the UK, Imperial College London is also progressing with its vaccine candidate and will look to move into clinical trials by mid-June, with larger scale trials in October.

A thousand healthy volunteers involved in the trial
For the Oxford Vaccine Group testing, up to 1,102 participants have been recruited across multiple study sites in Oxford, Southampton, London and Bristol.

Volunteers must be aged 18-55, and cannot have tested positive for COVID-19.

They must also be in good health, not be pregnant or breastfeeding, and must not have previously taken part in a trial with an adenoviral vaccine or received any other coronavirus vaccines.

Vaccinations staggered over the first five days
The volunteers have been randomly allocated to receive either the ChAdOx1 nCoV-19 vaccine or a licensed meningitis vaccine that will be used as a control for comparison.

The dose used in the trial was chosen based on previous experiences with other ChAdOx1-based vaccines.

Participants will not know whether they have received the COVID-19 vaccine or the control vaccine until the end of the trial.

On April 24, the first two participants were vaccinated, one with the ChAdOx1 nCoV-19 vaccine and one with the control vaccine. On day three, six more volunteers were vaccinated, half with the COVID-19 vaccine and three with the control vaccine. On the fifth day, researchers began vaccinating larger numbers of participants.

Symptoms tracked with a diary and blood tests
The participants were given an e-diary to record any symptoms they experience in the seven days after receiving the vaccine, and if they feel unwell for the following three weeks.

During a series of follow-up visits, blood samples will be taken to assess their immune response, and their observations checked.

If they develop COVID-19 symptoms during the study, they can contact a member of the clinical team, who will check if they have become infected with the virus.

If a participant becomes very unwell they will be reviewed by staff at the hospital.

Results depend on virus transmission rate
Statisticians will compare the number of infections in the control group with the number of infections in the vaccinated group.

Therefore, it is necessary for a small number of study participants to develop COVID-19.

How quickly researchers reach the numbers required depends on the levels of virus transmission in the community.

If transmission remains high, enough data may be available in a couple of months but if transmission levels drop, this could take up to six months.

Source: Published by sciencefocus

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Ajagbe Olufemi
Ajagbe Olufemi
15 days ago

I pray the vaccine works fine

Ogali Christian
Ogali Christian
15 days ago

God help us all

Chima franklyn
Chima franklyn
15 days ago

Good one there

Nwawuba Emmanuel Chibueze
Nwawuba Emmanuel Chibueze
15 days ago

I pray the vaccine works perfectly well so that everything will come back to normalcy, God will see us through.

Daniel Ntichika
Daniel Ntichika
15 days ago

Gud 2 hear

Uzomacomfort
Uzomacomfort
15 days ago

May God give all the researchers divine wisdom to get the right vaccine in Jesus name.amen

Umar Faruk
Umar Faruk
15 days ago

I pray the vaccine work well before this get out of hand

Gideon
Gideon
15 days ago

My prayers is that let the vaccine work because this covid 19 has killed a lot of people

Omenogor Lucky
Omenogor Lucky
15 days ago

That’s great to hear,I pray that things will go back to normal.

Osuji Caleb ikechi
Osuji Caleb ikechi
15 days ago

Good news, there’s hope ,there’s progress. Soon the world will be free from Covid -19

Fatima Abdullahi
Fatima Abdullahi
15 days ago

The death rate is just too much, I pray the vassine works

Ayodeji Adeniyi
Ayodeji Adeniyi
15 days ago

Yes of course, health is wealth

Ajagu Joseph Samson
Ajagu Joseph Samson
15 days ago

Thanks for the information

Adewole olatunde samuel
Adewole olatunde samuel
15 days ago

Dat is a great step coming from UK. I wish Nigeria government can emulate this by allowing our pharmacists and other medical professionals to look for ways to get d vaccine for covid19

Johnson Hernandez
Johnson Hernandez
15 days ago

Am happy ooo let the vaccine work thank god oo

Chetachi Nwabueze
Chetachi Nwabueze
15 days ago

I hope the vaccine development goes well

Ekigho Grace
Ekigho Grace
15 days ago

God will help us ooooooooo

Sammy alabi
Sammy alabi
15 days ago

let wait and see.. but I pray it work perfect

James Mamah
James Mamah
15 days ago

Just hope that the h trials become a success

Stanley
Stanley
15 days ago

may God heal the world

Ndumnwere Chima
Ndumnwere Chima
15 days ago

May God save us from this deadly virus.
I pray the vaccine works.

Emeghurhie Peter
Emeghurhie Peter
15 days ago

May this vaccine work well because the number of cases is rising everyday…they should be careful when using on human being…they should first of all try it on animal before injecting it in human body

Chukwuka Obiosa
Chukwuka Obiosa
15 days ago

Now my question is what is our government doing with all those funds aside to lock us up

Atte
Atte
15 days ago

I hope the vaccine works, I also hope it does not have negative effect on the volonteers.But what about the Madagasca herb?

Chisom Charles
Chisom Charles
15 days ago

O lord help us

Obiezu Emmanuel Onyedikachi
Obiezu Emmanuel Onyedikachi
15 days ago

It is only God that will help us

Obiezu Emmanuel Onyedikachi
Obiezu Emmanuel Onyedikachi
15 days ago

I pray that the vaccine works well

Idris yayah
Idris yayah
15 days ago

Impressive i pray this work out cos am tire of staying indoors.

Onafuwa Oluwasheyi Oladipo
Onafuwa Oluwasheyi Oladipo
15 days ago

Good one from Oxford University and other research institutions….. The end of Covid-19 is here after d clinical trials this I know

Ikechukwu Osadebe Harry
Ikechukwu Osadebe Harry
15 days ago

Covid-19 is a real killer,one just have to be very careful oo

Olayinka Njoku
Olayinka Njoku
14 days ago

Hmmm… But what about the magadascar covid 19 cure syrup. That one is not recognized by WHO because it comes from Africa..

Suleiman Abdullahi
Suleiman Abdullahi
14 days ago

September
Inshallah before then coronavirus shall have come to end

Nelson Joseph
Nelson Joseph
14 days ago

I wish them best of luck and hope it works out well

Akpan Citadel
Akpan Citadel
12 days ago

I’m really tired of the whole shit.
Need it to be over soon

Matthew chinedu
Matthew chinedu
9 days ago

I prey it works God will help us

Ajagbe Olufemi
Ajagbe Olufemi
9 days ago

China finally put us in a tight corner

Oghenekome Sylvester
Oghenekome Sylvester
8 days ago

God help us all

JOSEPH VICTOR MOSES
JOSEPH VICTOR MOSES
5 days ago

We don’t know how this vaccines is going to work right all we have to do is to be prayerful person and be so passionate about others God help us